Bacterial IsolateProfile in Gram-Negative Urinary Isolates: Role ofNitrofurantoin

Background: In current times epidemic drug resistance has renewed interest in drugs belonging to the yesteryears, most importantly Nitrofurantoin for urinary tract infections. Studies have reported that more than 90% of infections are due enteric Gram-negative organisms, which 80% E.coli.Objectives: To study bacterial profile isolates and evaluate role nitrofurantoin.Methods: We retrospectively evaluated 500 consecutive bacteriological nitrofurantoin sensitivity patients at a tertiary care facility India between January June 2022.\Results: had total Gram- negative isolates. 383 (76.6%) these were found be susceptible nitrofurantoin. E. coli alone constituted 343 (68.6%) Gramnegative isolates, 264 (76.96%) sensitive 20 (4%) Proteus 05 (1%) Citrobacter species isolated resistant 12 (80%) out 15 Acinetobacter All (100 %) Pseudomonas tested nitrofurantoin.Conclusion: is common uropathogens despite rise antibiotic resistance, it continues Resistance also being this calls judicious further use based on culture reports local prevalence data.International Journal Human Health Sciences Vol. 07 No. 02 April’23 Page: 162-165